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Dr. Lena C. Brundin, M.D., Ph.D. is a physician-scientist who is an expert in the role of inflammation and inflammatory metabolites in depression and suicidality. She serves as a Professor in the Department of Neurodegenerative Science at Van Andel Institute in Grand Rapids, Michigan.
Dr. Brundin received her M.D. and Ph.D. in neurobiology from Lund University in Sweden, where she also completed clinical training in psychiatry. Her research focuses on immune system dysregulation as a key driver of neuropsychiatric and neurodegenerative disorders—including major depressive disorder, suicide risk, Parkinson’s disease, and perinatal depression.
Dr. Brundin is best known for her discoveries linking inflammation and altered tryptophan-kynurenine metabolism to psychiatric illness. Her highly cited studies were among the first to demonstrate that elevated levels of inflammatory cytokines and neurotoxic kynurenine metabolites in cerebrospinal fluid are associated with suicidal ideation and behavior.
Her team has also made pivotal contributions to understanding mood disorders during pregnancy. She identified dysregulation of kynurenine pathway enzymes in the placenta as a potential contributor to severe postpartum depression, with implications for predictive biomarkers and early intervention in maternal mental health.
Dr. Brundin leads multiple NIH- and foundation-funded clinical trials and collaborates with the Michael J. Fox Foundation and international partners. Her translational research integrates psychiatry, neurology, women’s health and immunology, and is redefining how we detect, understand, and treat brain disorders driven by inflammation.
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Lena Brundin, PhD, Van Andel Research Institute |
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